Beta Blockers Pharmacology Nursing (Mechanism of Action) Selective and Nonselective


Beta Blockers Pharmacology Nursing (Mechanism of Action) Selective and Nonselective

Beta blockers pharmacology nursing review of the mechanism of action, side effects, and nursing implications of selective and nonselective beta blockers (beta adrenergic blockers).

Beta blockers work to block the beta receptors in the body. This will prevent norepinephrine and epinephrine from binding to the beta receptor sites. This results in decreasing the response of the sympathetic nervous system.

There are different types of beta blockers and the type depends on what beta receptor sites it blocks. There are beta 1, beta 2, and beta 3 receptor sites in the body.

Beta 1 receptors are mainly located in the heart and kidneys. Beta 2 receptors are located in the lungs (bronchioles), GI system, vascular smooth muscle, skeletal muscle, ciliary body of the eye etc. Beta 3 are located in the fatty/adipose tissue of the body.

Selective beta blockers, like Atenolol/Esmolol/Metoprolol, block only beta 1 receptors. Therefore, they are sometimes referred to as cardioselective.

Nonselective beta blockers, like Propranolol/Sotalol/Timolol, block BOTH beta 1 and beta 2 receptors. These medications should be avoided in patients with asthma and COPD because they block beta 2 receptors, which can lead to bronchoconstriction.

Please see the video for nursing implications for beta blockers.

#betablockers #pharmacology #cardiacpharmacology

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